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To Comment on the Philip Morris Products S.A. MRTP Applications You may to docket FDA-2017-D-3001 through February 11, 2019. Casio fx-115s vpam. There may be conflicting deadlines posted on regulations.gov and federalregister.gov.

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While we cannot control how information is displayed on those websites, the docket will remain open until February 11, 2019. The FDA filed for scientific review from Philip Morris Products S.A. (PMP S.A.) for its IQOS system and three types of HeatStick products on May 24, 2017. Due to the large size of these applications, FDA is posting the application documents in installments on a rolling basis as they are redacted in accordance with applicable laws. FDA completed posting the originally submitted applications on November 28, 2017. Please when materials from any MRTP applications under scientific review have been posted or check this webpage regularly. The most recently posted materials were made available on December 17, 2018.

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The following modules are currently publicly available: Originally Submitted Applications: • • • • • • • • • Amendments: • January 25, 2017 Amendment: (.zip – 260 KB) (added January 12, 2018) • February 8, 2017 Amendment: (.zip – 153 KB) (added January 12, 2018) March 16, 2017 Amendment: (.zip – 56 MB) (originally added January 12, 2018) FDA has also posted this amendment in 10 separate parts below. • (.zip - 233 MB) ( posted December 17, 2018) • (.zip - 233 MB) ( posted December 17, 2018) • (.zip - 937 MB) ( posted December 17, 2018) • (.zip - 582 MB) ( posted December 17, 2018) • (.zip – 1.0 GB) ( posted December 17, 2018) • (.zip - 1.9 GB) ( posted December 17, 2018) • (.zip - 3.2 GB) ( posted December 17, 2018) • (.zip - 5.1 GB) ( posted December 17, 2018) • (.zip - 3.4 GB) ( posted December 17, 2018) • (.zip - 4.7 MB) ( posted December 17, 2018) May 15, 2017 Amendment: (.zip – 32 GB) (added February 23, 2018) *This ZIP file includes several individual files. Depending on your internet connection speed and other factors, it may take a few minutes or up to several hours to download the ZIP file completely. FDA has also posted this amendment in 20 separate parts below. Siemens plc programming software. Temporary Compliance Waiver Notice The linked files may not be fully accessible to readers using assistive technology.